The long and narrow streets and the typical case a corte make the historical centre of Melissano really special. There used to be an imposing Castle too but now it does not exist any longer: it was situated in Piazza Vecchia ("Old Square"), it was built in the XIV century and it was commissioned by the noble vassal Amendolia. At Melisasno you can visit a lot of religious monuments such as  the Mother Church dedicated to the Madonna of the Rosary and to St Anthony. The jobs of constructions started in 1885 and finished in 1902. It was planned by the architect Ferdinando Campasena, and it has a very beautiful façade with a well decorated front door, two side-doors and   three ample windows. In this church with nave and two aisles you can admire some elegant altars and some interesting canvasses as that representing St Anthony, that was commissioned by the noble vassal De Franchis in the XVIII century. The Church of Jesus Saviour  has been built recently (1997) and it is marked by a very  modern and simple style. The Church of St Anthony was built in the XVI century. It has been restored a lot of times so far and during the last jobs of restorations some bones were recovered, thus proving the presence of ancient tombs inside the church. In the Church of the Immaculate, dating back to the XIX century, there is the statue of the Madonna of the Miracle,  protagonist of a miraculous event. According to a popular story in 1869, a terrible storm  started suddenly and then a terrible cyclone afflicted Melissano. The people, very frightened, tried to take refuge in the houses and when something terrible was to happen the  sun appeared  and the storm stopped. Straight away on the face of the statue of the Madonna of the Miracle some tears appeared mysteriously. The church is well decorated and,  inside, you can appreciate the elegant altars and a very interesting painting from the artistic point of view representing the Madonna of the Carmine. The Clock Tower was built at the beginning of the XX century and it was projected by the engineer Giovanni Marsano. Outside the urban centre there used to be the Abbey of St  Maria de Civo, built in the XI century. Now hardly some rests have left. In the open country there are some farms too as Coloni Farm dating back to the XIX century, and Cutinazzi Farm built in the XVIII century. The protector of this small town  is St Anthony from Padua, that is celebrated solemnly on June 13th.

The nickname of the inhabitants of Melissano is "cargnocculari" that literally  means frogs. They have this nickname because in the past when  the first residences were built there were marshes and ponds that  are the ideal habitat for these animals. After the jobs of reclamation, the swamps disappeared, but the inhabitants of Melissano have still this nickname